Who we are

A team dedicated to bring the best of allogenic T Cell medicine in a safe, accessible and affordable way

At Smart Immune, scientists and clinicians foster sharp understanding of T cell differentiation and an outstanding, 25-year experience in Hematopoeitic Stem Cell Transplantation (HSCT). Smart Immune provides a pioneering  biomimetic solution to ensure fast and fully functional recovery of a polyclonal T cell compartment within the first three months post-transplant, instead of the 12 months usually expected in human physiology.

Pr Marina Cavazzana
CMO

Marina is an internationally recognized pioneer in cell and gene therapy (+300 articles), a Member of the American medical academy, and recipient of the Beutler ASH award, the Prix Irene Joliot Curie, and Grand prix de l’Académie de Médicine. She directs the Biotherapy Clinical Investigation Center and the Biotherapy Department and she is Head of the gene therapy clinical department at Necker Children’s Hospital.

Marina lead the clinical strategy and clinical road map of Smart Immune.

Dr Fulvio Mavillio
CSO

Formerly Senior VP of Translational Science at Audentes Therapeutics and Professor of Molecular Biology at the University of Modena and Reggio Emilia, Modena, Italy,  Fulvio is an expert and pioneer in the fields of gene therapy and stem cell research. He has published over 180 articles in major international journals.  He has served as CSO of Genethon, France, as Director of Discovery of Molmed SpA , co-Director of the San Raffaele-Telethon Institute of Gene Therapy  and director of Discovery of MolMed SpA  in Milan.

Dr Karine Rossignol
CEO

Karine has more than 25 years’ managing experience in both industry and biomedical research institutes. She was CEO of the French Foundation for Hearing for 3 years and was co-secretary general of the Imagine Institute for Genetic Diseases during 10 years, where she was instrumental in structuring, developing, and raising funds for the institute. As a doctor of Pharmacy and a HEC Business School graduate, she brings a solid managing experience in both the public and the private sectors. She has 12-year international experience in international marketing in LVMH and L’Oreal.

Board of Directors

Sebastian Lombardo
Chairman of the Board of Directors
Chairman and CEO of Valtech

Sebastian has extensive and successful experience in creating, investing in, and managing several companies in the Digital and Technology Industry. He is currently Chairman and CEO of Valtech, and has a personal interest in immunology.

Dominique Constantini
Independent member
President and CEO of Ose Therapeutics

Dominique is an immunologist MD with more than 20 years of experience in the pharmaceutical industry. She has accompanied many therapeutic innovations internationally in the field of oncology. She founded BioAlliance Pharma and led the IPO of the company on Euronext. Currently, she is the president and CEO of OSE Therapeutics.

Fouzia Lagrisshi-Thodes
Independant member
CEO of DalCor

Fouzia is MD PfD and was previously Vice-President at Astra Zeneca and Roche in Global product& portefolio strategy. She has more than 20 years of pharmaceuticals industry experience in the United States and Europe working in clinical development, global product strategy, business development, marketing and licensing.

Scientific Advisory Board

Eliane Gluckman
Hematologist
Saint Louis Hospital, Paris

Eliane Gluckman, MD, is internationally recognised for her longstanding contributions to the advances in Bone Marrow and Cord Blood transplantation, several times awarded in this field. Pr. Gluckman is a founding member and former president of the European Group for Bone Marrow Transplantation. She is the founder and current president of EUROCORD.

Vanderson Rocha
Hematologist
Oxford Churchill Hospital, Sírio Libanês Hospital, São Paulo

Vanderson Rocha is the Director of the Hematology, Hemotherapy and Cell Therapy Service of the ICHC Medical Clinic Division I and Medical Coordinator of the Hematologic Diseases and Bone Marrow Transplantation Unit of the Sírio Libanês Hospital. Abroad he teaches hematology at Churchill Hospital – Oxford University Hospitals – NHS Trust (UK). He is Chairman of the Pró-Sangue Foundation.

James Di Santo
Immunologist
Pasteur Institute, Paris

James Di Santo received a MD/PhD from Cornell University Medical College and the Memorial Sloan–Kettering Cancer Center. He directed the Immunology Department of Pasteur Institute from 2002 to 2006. His research interests include defining the role of cytokines in lymphoid development and understanding the differentiation of natural killer cells and other innate lymphoid cells.

Marcel R.M. van den Brink, MD, PhD
Immuno Hematology
Memorial Sloan Kettering Cancer Center, New York

Head of the Division of Hematologic Malignances and Alan N. Houghton Chair at Memorial Sloan Kettering Cancer Center, New York, Marcel studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution. He holds a joint appointment in the Immunology and Transplantation Program of the Sloan Kettering Institute and is the Co-Director of the Parker Institute for Cancer Immunotherapy at MSKCC. He also serves as Chairman of the Board of DKMS, an international nonprofit organization devoted to bone marrow donor registration

Smart Immune T cell Progenitors breakthrough: reducing infections and GVHD post transplant while curing the underlying disease

Smart Immune is a clinical-stage biotherapeutics company focused on saving and improving lives by delivering to patients a new generation of T cell medicine: the T Cell Progenitors or ProTcell . Rapidly educated in the thymus to kill virus and cancer cells once infused, those pioneering ProTcell enable a rapid, multipotent and safe immune recovery post transplant, changing life expectancy for thousand of patients.

Its disruptive and proprietary ex vivo thymus technology can differentiate hematopoietic stem cell into T Cell progenitors in 7 days instead of the usual 12 months expected in human physiology with a 20/50 expansion rate. By ensuring a full and fast polyclonal immune recovery post transplant, Smart Immune can change prognosis for life-threatening conditions. This patented technology is applicable to all cell and gene therapies involving T cells.

Smart Immune is developing a diversified portfolio of novel treatments, which exhibits best-in-class results for fast and fully functional immune recovery within 3 months post-transplant. With two programs already in clinical stage for bubble  babies in Necker Enfants Malades, and  High risk adult AML Europe and a trial for high risk leukemia Leukemia ready to recruit at the automn 2021 , Smart Immune focus on getting a clinical validation of the the curative power of its ProTcell platform as early as 2024. A program dedicated to milli-fluidic automation has been integrated early on in the operational Road Map in order to  enable scale up and out of HSC-derived cell bioproduction.

With its headquarters in Paris, Smart Immune Research is hosted at Paris Biotech Santé and capitalise on GMP production facilities of Necker Children’s Hospital to pursue process development and production scale up, in support of the clinical development of its ProTcell platform.